Endocrine Abstracts

Background: Radiofrequency Echographic Multi Spectrometry (REMS) is a new ultrasound-based tool for bone mineral density (BMD) measurement, recently approved by FDA for the use in clinical routine to diagnose osteoporosis (OP) and to monitor bone changes. However, data on patients with secondary OP are not available. The aim of our study was to compare REMS and DXA ability in identifying clinical (cFX) and morphometric vertebral fractures (VFx) in patients with primary OP (pOP...

Primary hyperparathyroidism (PHPT) may occur sporadically or within MEN syndromes. It is classically thought that PHPT in MEN occurs at earlier ages than sporadic PHPT without significant differences in clinical and biochemical presentation. The aim of the study was to compare clinical and biochemical parameters between sporadic PHPT and MEN1 patients. The study included 41 genetically diagnosed MEN1 patients (14M, 27F) and 88 sporadic PHPT patients (24M, 64F) matched for age ...

ObjectiveSeveral studies showed that patients discontinuing denosumab (Dmab) may experience bone loss and incident vertebral fractures (VFx) due to a rebound bone turnover increase, suggesting the need of anti-resorptive (i.e. bisphosphonate BPs) therapy to mitigate this occurrence. However, the morphometric VFx (morphoVFx) incidence after Dmab discontinuation is unknown and scarce data are available about the BPs effect on BMD changes and Fx risk in thi...

We report on the clinical and biochemical outcomes in a 20-year-old male suffering from active craniofacial monostotic fibrous dysplasia (MFD) treated with the RANK-L inhibitor, Denosumab, following unsatisfactory responses to prior long-term bisphosphonates therapy. The patient had been treated over 9 years with pamidronate (cumulative dose of 81 mg), but experienced only mild reductions in pain scores. Following initiation of Denosumab 60 mg subcutaneously, bone pain and bon...

Primary hyperparathyroidism (PHPT) is associated with increased risk of kidney stones. Hypercalciuria and urine oxalate excretion are considered risk factors for urolithiasis in PHPT stone-formers. Recently, the anion-exchanger SLC26A6 has been involved in the oxalate metabolism. Slc26a6-null mice showed hyperoxalemia, hyperoxaluria resulting in dramatic calcium oxalate urolithiasis. We tested the hypothesis that urine oxalate excretion in PHPT patients might be modulat...

A peculiar characteristic of parathyroid tissue is the ability to spontaneously induce angiogenesis, to proliferate and to secrete PTH when autotransplanted in patients undergoing total parathyroidectomy. Since stem/progenitor cells have been involved in the process of tissue regeneration, we searched for putative parathyroid progenitors from human normal and tumoral parathyroids. By immunohistochemistry, FACS analysis and cell culture we identified parathyroid cells positive ...

Multiple endocrine neoplasia type 1 (MEN1) is a rare dominantly inherited neoplastic syndrome. Tipically, it affects three major locations: parathyroid, endocrine pancreas or duodenum (GEP) and anterior pituitary. MEN1 is caused by mutations in MEN1 gene and its testing is now used as a complement to clinical diagnosis which may be hindered by the variable penetrance and expression of the defects. Mutation carriers are life-long monitored, while unaffected relatives can avoid ...

Background: Cystic fibrosis-related bone disease (CFBD) is an emerging complication of cystic fibrosis (CF), especially in CF-lung transplant candidates for end-stage disease.Objectives: The assessment of vitamin D levels, bone mineral density (BMD) and morphometric and clinical prevalent fragility fractures in a cohort of young adults affected with CF awaiting lung transplantation for end-stage respiratory failure.Methods: In 42 C...

Background: fragility fractures (FX) occur frequently after lung transplantation (TX), with a higher rate (15-20%) in the first two years, which decreases subsequently. Patients affected from cystic fibrosis (CF) seem to have a lower FX risk in the first two years after TX as compared with those affected with other lung diseases (nCF). The aim of our study is to evaluate and compare the long-term skeletal outcome in CF and nCF patients after TX.Methods: ...

Most adrenal incidentalomas are benign and can be divided into nonfunctioning adrenal tumors (NFAT) and tumors with mild autonomous cortisol secretion (MACS). Several studies suggest that MACS may result in an increased risk for mortality and cardiometabolic disease. The cardiometabolic risk in MACS is possibly related to the increased frequency of cardiovascular risk factors such as diabetes mellitus (DM) and hypertension (HT) induced by cortisol excess. This is confirmed by ...